Experienced Physician; Peripheral Blood Counts; Neurological Examinations

Experienced Physician

• Altretamine should only be given under the supervision of a physician experienced in the use of antineoplastic agents.

Peripheral Blood Counts

• Peripheral blood counts should be monitored at least monthly, prior to the initiation of each course of altretamine, and as clinically indicated.

Neurological  Examinations

• Because of the possibility of  altretamine capsules-related neurotoxicity, neurologic examination should be performed regularly during therapy.