• Use by experience physician in patient with confirmed diagnosis of chronic myelogenous leukemia
• Bone Marrow Suppression: associated with use
• Reduce or stop dosage at first sign of any unusual depression of bone marrow function.
• Perform bone marrow examination if bone marrow status is uncertain.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

• Reduce or stop dosage at first sign of any unusual depression of bone marrow function.
• Perform bone marrow examination if bone marrow status is uncertain.
• Use with extreme caution in patients with prior radiation or chemotherapy
• Perform hematological testing weekly during therapy.

Patient Counseling Information

Busulfex

Myleran

Package Inserts

Busulfan