Warfarin Interaction

• Interaction with oral coumarin derivative anticoagulants. Altered coagulation parameters, bleeding and death have been reported with this combination.
• Increases in INR have occurred several days up to several months after initiating capecitabine, and in some cases, within one month after stopping the capecitabin.
• These events have occurred in patients with and without liver metastases.
• Age greater than 60 years and a diagnosis of cancer are independent risk factors for risk of coagulopathy.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

• INRs or prothrombin time monitoring required with great frequency and appropriate adjustment of anticoagulant dose
• Black box data revised November 2001

Patient Counseling Information

Xeloda

Package Inserts

Capecitabine