Midodrine

Supine Blood Pressure > 180 mmHg

  • Because midodrine can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care.
  • The indication for use of midodrine in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured one minute after standing, a surrogate marker considered likely to correspond to a clinical benefit.
  • At present, however, clinical benefits of midodrine, principally improved ability to carry out activities of daily living, have not been verified.

Monitoring data

  • Not recommended for use in patients with initial supine systolic blood pressure > 180 mmHg
  • Monitor supine and sitting blood pressures during therapy

Patient counseling

Communications

Package inserts

Additional information

Keywords: Proamatine
Updated: January 2018