Preterm Infant Deaths: have been reported after infusions. Autopsy revealed intravascular fat accumulation in the lungs. Carefully assess benefit/risk ratio prior to treatment
Total daily dose should not be exceeded (1 g fat/kg in 4 hours)
Premature and small for gestational age infants: should receive less than maximum recommended doses as they have poor clearance of intravenous fat emulsions
Monitor infants ability to eliminate infused fat (see monitoring)
Closely monitor ability to eliminate infused fat from circulation (serum triglycerides and/or plasma free fatty acids levels. The lipemia must clear between daily infusions.
Monitor hemogram, blood coagulation, liver function tests, plasma lipid profile, and platelet count (especially in neonates).