BlackBoxRX
 
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Midodrine

Supine Blood Pressure > 180 mmHg

  • Because midodrine can cause marked elevation of supine blood pressure, it should be used in patients whose lives are considerably impaired despite standard clinical care.
  • The indication for use of midodrine in the treatment of symptomatic orthostatic hypotension is based primarily on a change in a surrogate marker of effectiveness, an increase in systolic blood pressure measured one minute after standing, a surrogate marker considered likely to correspond to a clinical benefit.
  • At present, however, clinical benefits of midodrine, principally improved ability to carry out activities of daily living, have not been verified.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

  • Not recommended for use in patients with initial supine systolic blood pressure > 180 mmHg
  • Monitor supine and sitting blood pressures during therapy

FDA and Industry Communications

Patient Counseling Information

Package Inserts

Midodrine

Additional Information

Updated January 2018