Adrenal Crisis in the Setting of Shock, Severe Trauma or Infection

Mitotane can cause adrenal suppression and adrenal crisis in the setting of shock, severe trauma or infection.

• Advise patients of the signs and symptoms of adrenal suppression and to contact their healthcare provider immediately if shock, trauma, infection, or adrenal suppression occurs. Withhold mitotane before planned surgeries.
• Temporarily withhold mitotane during shock, trauma, infection or adrenal suppression [see Dosage and Administration (2.4)].
• Provide supportive care and administer systemic corticosteroids until recovery.