BlackBoxRX
 
We highly recommend enabling Javascript while using the BlackBoxRX site.

Pentostatin

Prior to Initiation of Therapy

Experienced Physician

  • Should be administered under the supervision of a physician qualified and experienced in the use of cancer chemotherapeutic agents.

Dose Related Toxicities

  • The use of higher doses than those specified (see DOSAGE AND ADMINISTRATION) is not recommended.
  • Dose-limiting severe renal, liver, pulmonary, and CNS toxicities occurred in Phase 1 studies that used pentostatin at higher doses (20-50 mg/m2 in divided doses over 5 days) than recommended.
  • In a clinical investigation in patients with refractory chronic lymphocytic leukemia using pentostatin at the recommended dose in combination with fludarabine phosphate, 4 of 6 patients entered in the study had severe or fatal pulmonary toxicity.

Not Recommended With Fludarabine

  • The use of pentostatin in combination with fludarabine phosphate is not recommended.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

  • Assess baseline renal function prior to therapy.
  • Perform complete blood cell counts and serum creatinine prior to each dose and at other appropriate times during therapy.

Patient Counseling Information

Package Inserts

Pentostatin

Additional Information

Updated January 2018