Quinidine Sulfate (warning removed)
- In many trials of antiarrhythmic therapy for non-life-threatening arrhythmias, active antiarrhythmic therapy has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease.
- In the case of quinidine used to prevent or defer recurrence of atrial flutter/fibrillation, the best available data come from a meta-analysis described in package insert under CLINICAL PHARMACOLOGY, Clinical Effects . In the patients studied in the trials there analyzed, the mortality associated with the use of quinidine was more than three times as great as the mortality associated with the use of placebo.
- Another meta-analysis, also described under CLINICAL PHARMACOLOGY, Clinical Effects [in the package insert], showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of any of a variety of alternative antiarrhythmics.
Patient Counseling Information
Updated January 2017