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Sotalol (Oral)

Life-Threatening Proarrhythmia

  • To minimize the risk of drug-induced arrhythmia, initiate or reinitiate oral sotalol in a facility that can provide cardiac resuscitation and continuous electrocardiographic monitoring.
  • Sotalol can cause life threatening ventricular tachycardia associated with QT interval prolongation.
  • If the QT interval prolongs to 500 msec or greater, reduce the dose, lengthen the dosing interval, or discontinue the drug.
  • Calculate creatinine clearance to determine appropriate dosing

Dose Selection, Special Cautions in Renal Impairment

  • For detailed instructions regarding dose selection, and special cautions for people with renal impairment, see DOSAGE AND ADMINISTRATION.

Betapace vs Betapace AF

  • Sotalol is also indicated for the treatment of life-threatening ventricular arrhythmias and is marketed under the brand name Betapace (sotalol hydrochloride tablets).
  • Sotalol AF is not approved for atrial fibrillation or flutter indication
  • Do not substitute Betapace (sotalol hydrochloride) for Betapace AF (sotalol hydrochloride AF). Betapace does not have atrial fibrillation indication or package insert information for patient


  • Creatinine clearance should be calculated prior to dosing

Patient Counseling Information

Package Inserts


Updated April 2020