- Risk of severe neurotoxic reactions is sharply increased in patients with impaired renal dysfunction or pre-renal
- Avoid concurrent use of nephrotoxic/neurotoxic drugs
MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA
- Renal function shuld be monitored carefully and patients with reduced function should have reduced doses.
- Peak serum concentrations in patients with renal dysfunctions < 20>
Patient Counseling Information
Updated January 2018