Teniposide

Myelosuppression; Hypersensitivity Reactions

Experienced Physician/Equipped Facilities

• Teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
• Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
• Severe myelosuppression with resulting infection or bleeding may occur.
• Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to teniposide.
• Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

• Epinephrine with or without corticosteroids and antihistamines have been used to alleviate hypersensitivity reaction symptoms.
• Perform baseline and periodic complete blood cell counts and assessments of renal and hepatic function during therapy.

Package Inserts

Teniposide

Additional Information

• PubMed - Teniposide and Myelosuppression
• PubMed - Teniposide and Hypersensitivity Reactions