Myelosuppression; Hypersensitivity Reactions
Experienced Physician/Equipped Facilities
- Teniposide injection) is a cytotoxic drug which should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
- Appropriate management of therapy and complications is possible only when adequate treatment facilities are readily available.
- Severe myelosuppression with resulting infection or bleeding may occur.
- Hypersensitivity reactions, including anaphylaxis-like symptoms, may occur with initial dosing or at repeated exposure to teniposide.
- Epinephrine, with or without corticosteroids and antihistamines, has been employed to alleviate hypersensitivity reaction symptoms.
MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA
- Epinephrine with or without corticosteroids and antihistamines have been used to alleviate hypersensitivity reaction symptoms.
- Perform baseline and periodic complete blood cell counts and assessments of renal and hepatic function during therapy.
Updated January 2018