Bone Marrow Suppression
- Busulfan Injection is a potent cytotoxic drug that causes profound myelosuppression at the recommended dosage.
- It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia.
- Appropriate management of therapy and complications is only possible when adequate diagnostic and treatment facilities are readily available.
MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA
- Reduce or stop dosage at first sign of any unusual depression of bone marrow function.
- Perform bone marrow examination if bone marrow status is uncertain.
- Use with extreme caution in patients with prior radiation or chemotherapy
- Perform hematological testing weekly during therapy.
Patient Counseling Information
Updated January 2018