Asparaginase - (black box removed upon last labeling revision)

• Experienced physician only in Hospital Setting
• Anaphylaxis
• Sudden death
• Special Handling Procedures
• Must be prepared to treat anaphylaxis at each administration of dose, including primary dose.
• Intradermal skin test should be performed prior to initial administration of this drug and repeated when > 1 week separates doses.
• See package insert for special handling instructions for preparation, administration and disposal of the drug.

Note:  Latest labeling (3/2007) does not include prior boxed warning.

Patient Counseling Information

• Elspar

Package Inserts

Asparaginase

Additional Information

• Anaphylaxis
• Sudden death
• Skin test