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Medroxyprogesterone acetate (Depo-Contraceptive Injection)

Injection: Loss of Bone Mineral Density

  • Women who use injectable medroxyprogesterone acetate may lose significant bone mineral density. Bone loss is greater with increasing duration of use and may not be completely reversible.
  • It is unknown if use of injectable medroxyprogesterone acetate during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture in later life.
  • Injectable medroxyprogesterone acetate should be used long-term (e.g., longer than 2 years) only if other methods of birth control are inadequate (see warning)

Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Package Inserts

Medroxyprogesterone acetate

Additional Information

Updated January 2020