BlackBoxRX
 
We highly recommend enabling Javascript while using the BlackBoxRX site.

Capecitabine

Warfarin Interaction

  • Interaction with oral coumarin derivative anticoagulants. Altered coagulation parameters, bleeding and death have been reported with this combination.
  • Increases in INR have occurred several days up to several months after initiating capecitabine, and in some cases, within one month after stopping the capecitabin.
  • These events have occurred in patients with and without liver metastases.
  • Age greater than 60 years and a diagnosis of cancer are independent risk factors for risk of coagulopathy.

MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

  • INRs or prothrombin time monitoring required with great frequency and appropriate adjustment of anticoagulant dose

Patient Counseling Information

Xeloda

Package Inserts

Capecitabine

Additional Information

Updated January 2018