Tizanidine*

Labeling for this product contains a bolded warning at the BEGINNING of the package insert that is not boxed.

Pharmacokinetic Differences between Zanaflex (Tizanidine) Capsules and Zanaflex (Tizanidine)Tablets

• Zanaflex capsules are not bioequivalent to Zanaflex tablets in the fed state.
• The prescriber should be throroughly familiar with the complex effects of food on tiaznidine pharmacokinectics (see Pharmacokinetcs and Dosage and Administration)

Package Inserts

Tizanidine

Additional Information

• PubMed - Tizanidine and Pharmacokinetic Differences between Zanaflex (Tizanidine) Capsules and Zanaflex (Tizanidine)Tablets