BlackBoxRX
 
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Cisapride (removed from Market 2000)

Cardiovascular

  • Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillaton, torsades de pointes, and QT prolongation.
  • Risk factors include concurrent therapy with drugs known to cause QT prolongation, depleted serum electrolytes.

Drug Interactions

  • Contraindicated with numerous drugs including those known to cause QT prolongation (tricyclics, certain antipsychotics) or CYP 450 3A4 inhibitors (fluconazole, ketoconazole, itraconazole).
  • See package insert
  • Do not exceed recommended doses

Note:  This drug was withdrawn from market in 2000 and only available via restricted distribution.


MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

  • Perform 12 ECG lead prior to administration
  • Do not initiate therapy if QTc > 450 msec
  • Serum electrolytes and creatinine assessed prior to therapy and whenever condition develops that may affect electrolyte balance or renal function.
  • If syncope, rapid or irregular heartbeat develops stop drug.
  • Drug withdrawn in 2000 and is available only via restricted distribution and registration program

Patient Counseling Information

Medication Guides

Patient Medication Guide

Package Inserts

Cisapride

Additional Information

Updated January 2018