Cisplatin

Nephrotoxicity; Myelosuppression

  • Experienced physician in the use of cancer chemotherapy in an equipped facility that provides appropriate management of therapy and complications.

Nephrotoxicity

  • Cumulative
  • Dose related and severe

Myleosuppression

  • Dose related and severe

Nausea and Vomiting

  • Dose related and severe

Ototoxicity

  • May be pronounced in children

Anaphylactic like reactions

  • Anaphylactic reactions may occur within minutes of cisplatin administration. Epinephrine, corticosteroids, and antihistamines may alleviate symptoms.

Avoid overdose or confusion with carboplatin and carboplatin-AQ

  • Prevent inadvertent overdoses: doses > 100 mg/m2/cycle once every 3 to 4 wks rarely used
  • Avoid confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle

Monitoring data

  • Ototoxicity manifested as tinnitus and/or loss of high frequency hearing. Occasionally deafness is significant.
  • Anaphylactic reactions may occur within minutes of cisplatin administration. Epinephrine, corticosteroids, and antihistamines may alleviate symptoms.
  • Prevent inadvertent overdoses: doses > 100 mg/m2/cycle once every 3 to 4 wks rarely used
  • Avoid confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle

Package inserts

Cisplatin

Additional information

Updated: January 2018