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Quinine Sulfate

No Benefit in Leg Cramps; Hematologic Risks

  • No Benefit in Treatment/Prevention of Nocturnal Leg Cramps: Risk of Hematologic Reactions Quinine sulfate use for the treatment or prevention of nocturnal leg cramps may result in serious and life-threatening hematologic reactions, including thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP). Chronic renal impairment associated with the development of TTP has been reported. The risk associated with quinine sulfate use in the absence of evidence of its effectiveness in the treatment or prevention of nocturnal leg cramps outweighs any potential benefit

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Quinine

Updated January 2018