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Contraceptives(Containing estrogen)

Cigarette Smoking Risk; Risk of Cardiovascular Disease

Cigarette Smoking And Risk of Cardiovascular Disease

  • Cigarette smoking increases the risk of serious cardiovascular side effects from hormonal contraceptive use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, oral contraceptives are contraindicated in women who are over 35 years of age, and smoke..

Sexually Transmitted Disease Statement  

  • Note: In most oral contraceptive package inserts, the following statement is provided in bolded lettering at the top of the insert but IS NOT boxed.
  • Patients should be counseled that this product does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

 The following contraceptive combinations/formulations contain the above statements:

Oral Formulations,

  • Ethinyl Estradiol/Desogestrel
  • Ethinyl Estradiol/Drospirenone
  • Ethinyl estradiol/Drospirenone/Levomefolate
  • Ethinyl Estradiol/Ethyndiol Diacetate
  • Ethinyl Estradiol/Levonorgestrel
  • Ethinyl Estradiol/Levonorgestrel/Ferrous Fumarate
  • Ethinyl Estradiol/Norethindrone
  • Ethinyl Estradiol/Norethindrone Acetate
  • Ethinyl Estradiol/Norgestimate
  • Ethinyl Estradiol/Norgestrel
  • Norethindrone/Mestranol

Transdermal Formulations

  • Ethinyl Estradiol/Norelgestromin


  • Ethinyl Estradiol/Etonogestrel
  • Segesterone Acetate/Ethinyl Estradiol 

FDA and Industry Communications

Additional Information

Updated September 2018