- Severe and sometimes fatal hepatotoxicity has been observed in clinical trials.
- Monitor hepatic function prior to and during treatment.
- Interrupt and then reduce or discontinue regorafenib for hepatotoxicity as manifested by elevated liver function tests or hepatocellular necrosis, depending upon severity and persistance [See Dosage and Administration, Warnings and Precautions]
Patient Counseling Information
Updated January 2018