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Serious Psychiatric and Behavioral Reactions

  • Serious or life-threatening psychiatric and behavioral adverse reactions including aggression, hostility, irritability, anger, and homicidal ideation and threats have been reported in patients taking perampanel.
  • These reactions occurred in patients with and without prior psychiatric history, prior aggressive behavior, or concomitant use of medications associated with hostility and aggression.
  • Advise patients and caregivers to contact a healthcare provider immediately if any of these reactions or changes in mood, behavior, or personality that are not typical for the patient are observed while taking perampanel or after discontinuing.
  • Closely monitor patients particularly during the titration period and at higher doses.
  • Perampanel should be reduced if these symptoms occur and should be discontinued immediately if symptoms are severe or are worsening.

Patient Counseling Information

Medication Guides

Patient Medication Guide

Package Inserts


Updated May 2016