Supine Hypertension

• Monitor supine blood pressure prior to and during treatment and more frequently when increasing doses.
• Elevating the head of the bed lessens the risk of supine hypertension, and blood pressure should be measured in this position.
• If supine hypertension cannot be managed by elevation of the head of the bed, reduce or discontinue NORTHERA [see Warnings and Precautions (5.1)].