Buprenorphine (Subdermal Implant)
Implant Migration, Protrusion, Expulsion, and Nerve Damage Associated with Insertin and Removal
- Insertion and removal of PROBUPHINE are associated with the risk of implant migration, protrusion, expulsion, and nerve damage resulting from the procedure.
PROBUPHINE is available only through a restricted program called the PROBUPHINE REMS Program.
FDA and Industry Communications
Approved Risk Evaluation and Mitigation Strategies (REMS)
Patient Counseling Information