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Desmopressin Acetate Nasal Spray (Noctiva)


  • NOCTIVA can cause hyponatremia, which may be life-threatening if severe.  
  • NOCTIVA is contraindicated in patients at increased risk of severe hyponatremia, such as patients with excessive fluid intake, illnesses that can cause fluid or electrolyte imbalances, and in those using loop diuretics or systemic or inhaled glucocorticoids.
  • Ensure serum sodium is normal before starting or resuming NOCTIVA. Measure serum sodium within seven days and approximately one month after initiating therapy or increasing the dose, and periodically during treatment. More frequently monitor serum sodium in patients 65 years of age and older and in patients at increased risk of hyponatremia.
  • If hyponatremia occurs, NOCTIVA may need to be temporarily or permanently discontinued.

Patient Counseling Information

Medication Guides

Patient Medication Guide

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Desmopression Acetate Nasal Spray

Updated January 2018