Risks From Concomitant Use With Opioids

Risk From Concomitant use with opioids; Abuse, Misuse, and Addiction; Dependence and Withdrawal Reactions 

• Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation (7.1).
• The use of benzodiazepines, including Halcion, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing Triazolam and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction (5.2).
• The continued use of benzodiazepines, including Triazolam, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of Triazolam after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue Triazolam or reduce the dosage (5.3).

Because Triazolam can cause drowsiness and a decreased level of consciousnes, patients particularly the elderly, are at higher risk of falls.