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Plazomicin

Nephrotoxicity, Ototoxicity, Neuromuscular Blockade and Fetal Harm

Nephrotoxicity

  • Nephrotoxicity has been reported with ZEMDRI. The risk of nephrotoxicity is greater in patients with impaired renal function, the elderly, and in those receiving concomitant nephrotoxic medications.

Ototoxicity

  • Ototoxicity, manifested as hearing loss, tinnitus, and/or vertigo, has been reported with ZEMDRI. Symptoms of aminoglycoside associated ototoxicity may be irreversible and may not become evident until after completion of therapy.

Neuromuscular Blockage

  • Aminoglycosides have been associated with neuromuscular blockade. During therapy with ZEMDRI, monitor for adverse reactions associated with neuromuscular blockade particularly in high-risk patients.

Fetal Harm

  • Aminoglycosides, including ZEMDRI can cause fetal harm when administered to a pregnant woman.

Patient Counseling Information

Package Inserts

Plazomicin

Updated July 2018