Fam-Trastuzumab Deruxtecan-nxki
Interstitial Lung Disease and Embryo-Fetal Toxocity
- Interstitial Lung Disease (ILD) and pneumonitis, including fatal cases, have been reported with ENHERTU.
- Embryo-Fetal Toxicity: Exposure to ENHERTU during pregnancy can cause embryo-fetal harm. Advise patients of these risks and the need for effective contraception.
Monitoring data
- Monitor for and promptly investigate signs and symptoms including cough, dyspnea, fever, and other new or worsening respiratory symptoms.
Patient care
- Permanently discontinue ENHERTU in all patients with Grade 2 or higher ILD/pneumonitis.
- Advise patients of the risk and the need to immediately report symptoms.
Patient counseling
Medical guidelines
Package inserts
Keywords: Enhertu
Updated: August 2022