Renal Impairment

• Renal impairment, including minimal change disease, acute and chronic interstitial nephritis and renal failure, has been reported in patients given products that release mesalamine in the gastrointestinal tract. Evaluate renal function prior to initiation of GIAZO and periodically while on therapy. Evaluate the risks and benefits of using GIAZO in patients with known renal impairment, a history of renal disease or taking nephrotoxic drugs