BlackBoxRX
 
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Fat Emulsions (intravenous)

Preterm InfantĀ  Deaths

  • Preterm Infant Deaths: have been reported after infusions. Autopsy revealed intravascular fat accumulation in the lungs. Carefully assess benefit/risk ratio prior to treatment
  • Total daily dose should not be exceeded (1 g fat/kg in 4 hours)
  • Premature and small for gestational age infants: should receive less than maximum recommended doses as they have poor clearance of intravenous fat emulsions
  • Monitor infants ability to eliminate infused fat (see monitoring)

Also seeĀ Fat Emulsions (Intravenous) (updated)


MONITORING RECOMMENDATIONS RELATED TO BLACK BOX DATA

  • Closely monitor ability to eliminate infused fat from circulation (serum triglycerides and/or plasma free fatty acids levels. The lipemia must clear between daily infusions.
  • Monitor hemogram, blood coagulation, liver function tests, plasma lipid profile, and platelet count (especially in neonates).

Additional Information

Updated July 2018